NFE2L2 and cancer: One study demonstrated that PC-3 and DU-145 cells differed significantly in their radiosensitivity due to variations in basal and induced Nrf2 (Nuclear Factor Erythroid 2-Related Factor-2) expression levels24.This basic leucine zipper transcription factor modulates cell inflammatory and immune response by inducing the transcription of antioxidant enzymes, which have a role in maintenance of cancer cell survival and disease progression22.