Based on the GO and KEGG database analyses of lncRNAs, protein-coding genes, and mRNAs, up-regulated genes were significantly enriched for renin-angiotensinogen system, endocrine and other factor-regulated Ca2+ reabsorption, and taurine and hypotaurine metabolism in db/db diabetic hearts without DCM and for renin-angiotensinogen system, endocrine and other factor-regulated Ca2+ reabsorption, and chemokine signaling pathway in db/db diabetic hearts with DCM. Here, REN is linked to familial dilated cardiomyopathy.