However, echinomycin inhibited PD-L1 upregulation induced by DS-5272 in Gr-1+ MLL-AF9 cells (Fig. 8c), and combined treatment of DS-5272 and echinomycin significantly prolonged the survival of leukemia mice than treatment with either DS-5272 or echinomycin alone (Fig. 8d). Here, KMT2A is linked to leukemia.