Consequently, we compared the CXCR4-binding affinity of FRM001 and its natural gallium (Ga), natural lutetium (Lu), and natural yttrium (Y) complexes in CCRF-CEM, a human acute lymphoblastic leukemia cell line expressing endogenous CXCR434, using LY2510924 and other CXCR4-targeting molecules as references. This evidence concerns the gene CXCR4 and acute lymphoblastic leukemia.