Consistent with the severe phenotype of FH, the maximum documented LDL-C in individuals with pathogenic LDLR or APOB variants was 2.49 SD (95% CI: 2.33, 2.65) and 1.42 SD (95% CI: 1.21, 1.62) higher than variant-negative individuals from the general population, respectively. Here, APOB is linked to familial hyperaldosteronism.