Prompted by the results that significant increased YTHDF1 expression was observed in NSCLC tissues and cancerous cell lines (Fig. 2, Supplementary Fig. 2), we further surveyed the protein expression and cellular location of YTHDF1 in NSCLC (including lung SCC and ADC) and noncancerous control lung tissues (NCLT) by immunohistochemical staining (IHC) using tissue microarray. This evidence concerns the gene YTHDF1 and AIDS dementia complex.