YTHDF1 and cancer: Because hypoxia-driven molecular event changes have been well established to be able to drive drug resistance, enhance epithelial-to-mesenchymal transition, remodel the extracellular matrix, support cancer stem cells, and facilitate evasion from immune surveillance in NSCLC and other hypoxic tumors31, we then decided to focus on the functional roles of YTHDF1 in NSCLC.