Mechanistic studies indicate that ablation of YTHDF1 decreases translational efficiency of the m6A-modified Keap1 transcript in an oxidative stress state induced by DDP, which in turn activates the antioxidant ROS clearance system (Nrf2-AKR1C1) leading to DDP resistance and a worse clinical outcome for NSCLC patients after platinum based chemotherapy. The gene discussed is YTHDF1; the disease is non-small cell lung carcinoma.