Consistently, a lower proliferation rate evidenced by Ki67 staining and an increase of CC3-positive cells were detected in lung tumors from KPY (or KY) mice compared to the KP (or K) mice, suggesting that YTHDF1 deletion had an inhibitory effect on tumor cell growth in vivo (Fig. 3j, k, Supplementary Fig. 3g, h). This evidence concerns the gene MKI67 and neoplasm.