Except for TEX2 and YTHDF1, most of the top two ranked positively selected genes from individual domestic animals, EPAS1 and HBB in dog, AKAP13 and PAPSS2 in horse, IFNLR1 and MBD3 in pig, BIRC7 and YTHDF1 in cattle, TEX2 and IKZF1 in sheep, DSG3 and NOL4 in goat, have been documented to play pivotal roles in different cancer types (Fig. 1c, d; see Supplementary Data 2). This evidence concerns the gene MBD3 and cancer.