Different from our observation that YTHDF1 low expression correlates with worse NSCLC clinical outcome by IHC analysis using tissue microarray, another study using TCGA RNA-seq data showed that YTHDF1 was upregulated in hepatocellular carcinoma (HCC), which correlated with significant shorter OS and DFS survival rate65. This evidence concerns the gene YTHDF1 and hepatocellular carcinoma.