AKR1C1 and AIDS dementia complex: To examine whether this was true in vivo, we performed IHC in KP and KPY mouse ADC tumors, and found that much more Keap1, albeit with moderate Nrf2 and AKR1C1 proteins, were detected in KP mouse tumors, whereas less Keap1 and much Nrf2 and AKR1C1 proteins, both in the cytosol and nuclear fractions, were observed in KPY mouse tumors (Fig. 5c).