MMP2 and neoplasm: Corroborated evidence suggests the presence of Cys2/His2zinc-finger motifs in carboxy-terminal domain of Klf4 confers preferential binding to GC/GT-rich or CACCC element sequences in its target gene promoter and enhancer regions followed by expression changes of broad array of genes covering cell cycle and proliferation, such as p21, p27, p5713–15, and tumor metastasis like matrix metalloproteinase 2 (MMP-2) and E-cadherin16,17.