SMAD2 and Ataxia: Using Enrichr analysis [56], we found that most (18/35 > 51%) class 1 modules are enriched for genes significantly associated with the OMIM disease terms “epilepsy,” “seizures,” or “ataxia.” Conversely, the genes that occur most commonly in class 3 modules (UBC, EP300, SMAD2, CSNK2A1, and ABL1) are associated with autism and/or intellectual disability [62, 71–73], and most (44/55 = 80%) class 3 modules are enriched for genes associated with the term “autism” (Additional file 5: Table S4).