However, with further aging, testosterone and insulin-like growth factor-1 levels in males decrease significantly, resulting in rapid loss of muscle mass and strength, which greatly increase the risk of sarcopenia in elderly males [26]; (2) although the AWGS recommended using height-adjusted skeletal muscle mass instead of weight-adjusted skeletal muscle mass to diagnose sarcopenia, several studies have suggested that low muscle mass identified by a weight-adjusted muscle index was more suitable for overweight and obese people [27]. This evidence concerns the gene IGF1 and sarcopenia.