Also Duan et al., 2013 showed that SALL4 mRNA expression significantly decreased at CR in AML and increased slightly higher in relapse than in de novo leukemia group, but the difference was not statistically significant (P > 0.05) and Jianghua et al., 2014, also found, SALL4 mRNA expression is significantly decreased in complete remission stage (median: 0.98) than in acute phase (median: 28.6) (p<0.001). The gene discussed is SALL4; the disease is leukemia.