In the deficient patients with older age, BMI (≥23 kg/m2), advance stage, lymph node metastasis, negative for PgR, HER-2, P53, Ki-67, and positive for ER showed significantly poorer 5 year-survival rate compared to their sufficient counterparts (p = 0.003, 0.007, 0.024, 0.001, 0.001, 0.001, 0.001, 0.027, and 0.012, respectively) (Table 2). This evidence concerns the gene ESR1 and metastatic malignant neoplasm in the lymph nodes.