GPT and hepatocellular carcinoma: The significant decline in serum ALP, AST and ALT enzymes activity as well as urea and creatinine serum levels in HCC bearing rats treated with compound 5 (pyrazole derivative) comes in line with the results obtained by Shabbir et al., (2009) who recorded insignificant change in serum AST, ALT, urea and creatinine values in pyrazole compound- treated rats in comparison with the controls.