FOXP3 and hepatocellular carcinoma: Prevalence of T-regs (CD4+CD25+FOXP3+) in peripheral blood and tumor infiltrating of HCC patients lead to an unfavorable prognostic, promote disease progression and may prevent effective antitumor immune responses (Ormandy et al., 2005; Fu et al., 2007; Kobayashi et al., 2007; Mathai et al., 2012).