Notably, in inherited genetic mutations, such as catecholaminergic polymorphic VT (CPVT), the fundamental step of arrhythmogenesis is SCR due to mutations in either RyR2 (CPVT-1) or CASQ2 (CPVT-2) [65,66]. Here, CASQ2 is linked to catecholaminergic polymorphic ventricular tachycardia.