CACNA2D1 and Brugada syndrome: Furthermore, mutations and genetic defects in the genes CACNA1C, CACNB2, and CACNA2D1 (encoding components of LTCC) may result in various arrhythmogenic syndromes like the Brugada syndrome [82,83], Brugada syndrome with short QT duration [83,84], short QT syndrome [83,84,85], early repolarization syndrome [82,86] and idiopathic ventricular fibrillation (VF).