Deletion of CCL5 in ApoE−/− mice reduces atherosclerosis in a CCR5-dependent-manner [386], and in [44AANA47]-RANTES, which prevents CCL5 ligation with glycosaminoglycans, reduces atherosclerosis, and increases plaque stability in LDLR−/− mice [387]. The gene discussed is CCR5; the disease is atherosclerosis.