TGFB1 and neoplasm: A compelling body of evidence supports the role of platelets in cancer progression: platelets have been demonstrated to promote tumor growth, to induce tumor angiogenesis, to activate tumor invasion by inducing epithelial-mesenchymal transition via TGFβ/SMAD signaling, and to support metastasis by facilitating tumor cell arrest and attachment to the endothelium, extravasation and seeding [5].