We show that Gal and the NGGAs exhibit profound anti-PC activities by inhibiting cell proliferation (of both drug-naïve and drug-resistant PC cells), colony formation, cell migration, invasion, and putative stem cell markers and reversed the expression of epithelial-to-mesenchymal transition (EMT), suggesting a direct inhibitory effect on the neoplastic process. Here, GAL is linked to pachyonychia congenita.