The encouraging conception of simultaneous effects of proteotoxic stress combined with a suppression of the heat shock response through HSF1 was further exploited and extended by Bustany and co-authors who reported that blocking HSF1 with KNK-437 in combination with bortezomib exhibited additive effects on apoptosis induction in multiple myeloma cells from groups of patients with bad prognosis [54]. This evidence concerns the gene HSF1 and AL amyloidosis.