Neuropeptides like calcitonin gene-related peptide (CGRP), corticotropin-releasing hormone (CRH), melanocyte-stimulating hormone (MSH), pituitary adenylate cyclase-activating polypeptide (PACAP), proopiomelanocortin peptides (POMC peptides), secretoneurin (SN), urocortin, vasointestinal polypeptide (VIP), and neurotensin (NT) serve as markers in the diagnosis of infection in the most severe stages of foot diabetic disease, especially in osteomyelitis. This evidence concerns the gene CRH and infection.