WNT10A pathogenic variants have been reported to cause highly variable disease manifestations, including dry hair, pilar keratosis, palmar erythema and keratoderma, severe hypodontia, onychodysplasia, smooth tongue, and hyperhidrosis of palms and soles, sparse eye-brows, dystrophic finger and toenails [22]. The gene discussed is WNT10A; the disease is tooth agenesis.