WNT10A pathogenic variants have been reported to cause highly variable disease manifestations, including dry hair, pilar keratosis, palmar erythema and keratoderma, severe hypodontia, onychodysplasia, smooth tongue, and hyperhidrosis of palms and soles, sparse eye-brows, dystrophic finger and toenails [22]. Here, WNT10A is linked to Palmoplantar keratoderma.