Heterozygous or biallelic variations in specific genes, including EDA [Ectodysplasin-A, OMIM *300451), EDAR (Ectodysplasin-A receptor, OMIM *604095], EDARADD [Ectodysplasin-A Receptor Associated Death-Domain, OMIM *606603], IKBKG [Inhibitor of Nuclear Factor Kappa B (NF-kB) Kinase Subunit Gamma, OMIM *300248] and TRAF6 [Tumour Necrosis Factor (TNF) receptor-associated factor 6, OMIM *602355] have been reported to cause the pathogenicity of HED. The gene discussed is TRAF6; the disease is hypohidrotic ectodermal dysplasia.