In conclusion, the present study provides new information about the functional role of GAS5 in IBD patients: The lncRNA seems to be regulated by pro-inflammatory factors and could have an important role in mediating tissue damage by modulating the expression of MMP2 and MMP9. In the future, the functional role of intestinal epithelium should be also investigated in this context using an innovative platform such as intestinal organoids. The gene discussed is MMP9; the disease is inflammatory bowel disease.