SHANK2 and Anxiety: In a Shank2-mutant mouse model of ASD, Won et al. reported marked decrease in NMDA (N-methyl-D-aspartate) glutamate receptor (NMDAR) function which was accompanied by ASD-like behaviors including impaired social interaction, reduced social communication by ultrasonic vocalizations, and repetitive behavior, increased anxiety-like behavior and impaired spatial learning and memory.