Additionally, in overweight/obese subjects, C/EBP-α expression remain correlated with adipogenic and inflammatory factors (negatively correlated with PPAR-γ and NF-κB expression and positively correlated with PPAR-γ methylation (p < 0.05)), while in overweight/obese CRC patients, C/EBP-α expression also remains correlated with glucose metabolism (HOMA-IR and insulin levels (p < 0.05)). This evidence concerns the gene INS and colorectal carcinoma.