PPARG and obesity due to melanocortin 4 receptor deficiency: However, in our results, no significant difference was found in PPAR-γ expression in adipose tissue in the presence of CRC, although we found a negative correlation between the PPAR-γ gene expression and methylation in the overweight/obesity state (overweight/obese subjects and overweight/obese CRC patients), suggesting that PPAR-γ expression and methylation in adipose tissue seem to be more important in the context of the obesity rather than CRC.