PPAR-γ expression seems to have a close relationship with overweight/obese subjects, since it was correlated with adipogenic and inflammatory factors (positively correlated with PGC-1α and NF-κB expression and negatively correlated with PPAR-γ methylation (p < 0.05)), while PPAR-γ methylation was more related to anthropometric data (waist circumference) in nonobese subjects and nonobese CRC patients. The gene discussed is NFKB1; the disease is colorectal carcinoma.