CEBPA and neoplasm: A study showed that C/EBPα was upregulated in CRC tumor, promoted tumor growth both in vitro and in vivo, and acted as an oncogene in CRC, suggesting that C/EBP-α seems to play a promoting role in colorectal tumorigenesis and progression [11], while other study suggested C/EBP-α as a tumor suppressor gene because downregulation of C/EBP-α was presented in various tumors and showed correlation with progression, poor prognosis, and tumor size [9].