Our results, obtained from a series of young and otherwise healthy subjects, showed that obesity influenced circulating levels of many of the cytokines evaluated here at fasting, resulting in increased circulating concentrations of PAI-1, chemerin and adipsin and reduced levels of omentin-1 and FGF-23, when compared with non-obese individuals. The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.