CXCR2 and pancreatic neoplasm: Similarly, CXCR2 signaling, a G-protein-coupled receptor for human CXC chemokines including CXCL1, CXCL2, CXCL3, CXCL5, and CXCL8, implicated in the regulation of neutrophils and migration of MDSCs, appears to play a critical role in the invasiveness, metastatic potential, or poorer prognosis in the preclinical and clinical settings of malignancies including pancreatic cancer [47,59,60,61,62,63,64].