Zhao and colleagues demonstrated an increased frequency of MDSCs in the blood, lymphatic organs and pancreas during early stages of tumor development, which further increased upon tumor progression in EL-TGF-α/p53−/− mice compared to EL-TGF-α/p53+/− mice with premalignant lesions, and wild-type (WT) mice harboring subcutaneous mPAC tumors [39]. The gene discussed is TGFA; the disease is neoplasm.