This system facilitated the depletion of all CD11b+ myeloid cell subsets including MDSCs upon the treatment with diphtheria toxin (DT), which prevented the formation of pancreatic intraepithelial neoplasia (PanIN) during the initiation phase of pancreatic carcinogenesis, and also caused tumor growth arrest or tumor regression of pre-established tumors [19]. Here, ITGAM is linked to neoplasm.