The study of Umemura et al. [87] claims that the autophagy flux protein p62 can initiate HCC through activation of nuclear factor erythroid 2-related factor 2 (NRF2) and MTORC1 and induction of c-myc to improve cell survival of HCC under high oxidative stress. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.