The stress-induced impaired autophagy could provide growth advantage through membrane-bound tyrosine kinase receptors such as EGFR, insulin-like growth factor receptor (IGFR), endothelial growth factor receptor (IGFR), platelet-derived growth factor receptor (PDGFR) and could lead to activation of RAS/RAF/MEK/ERK signaling, increased cell growth and differentiation, and eventually to cancer. The gene discussed is IGF1R; the disease is cancer.