MAPT and Parkinson disease: In any case, protein aggregates are the major hallmarks of numerous neurodegenerative and metabolic disorders, and many central nervous system pathologies are associated with protein aggregation, such as amyloid-β peptide (Aβ) and tau protein aggregates in Alzheimer’s disease (AD), α-synuclein in Parkinson’s disease (PD), and the huntingtin protein in Huntington’s disease [2].