In MCF7 BC cells, GEN dose-dependently (1–20 μM) decreased the basal expression of CYP1A1 and CYP1B1 [79], but did not antagonize the TCDD-dependent (5 nM) activation of a reporter system at 1 and 10-μM doses [80]. The gene discussed is CYP1B1; the disease is breast cancer.