CYP1A1 and hepatocellular carcinoma: In murine hepatoma Hepa-1c1c7 cells, GEN dose-dependently inhibited (0.1–20 μg/mL) TCDD-mediated activation of an XRE-driven reporter system, and in human HepG2 cells, GEN (50 μM) repressed the basal and TCDD-dependent expression of CYP1A1 [78].