TNF-α −308A allele has been reported to increase the risk of many diseases, such as cerebral malaria, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis, Crohn’s disease, cancer, and coronary heart disease (CHD) [12,26]. This evidence concerns the gene TNF and systemic lupus erythematosus.