STAT3 and head and neck squamous cell carcinoma: Surprisingly, in HNSCC FaDu cell line, RV almost abolished the phosphorylation of STAT3 through the activation of SOCS-1 (a negative regulator of STAT3), suppressed cell proliferation, induced apoptosis and at concentration of 100 μM it was able to radiosensitize cells irradiated with a 10 Gy dose of photon beam [29].