In human glioblastoma U87 cell line, the treatment with Curcumin enhanced the effects induced by 3 Gy of X-ray in a dose-dependent manner ranging from 5 to 10 μM, including: reduction of cell viability; arrest of cell cycle in G2/M phase (which is the most sensitive step to radiation); inhibition of two master regulators of tumor progression, the Map Kinases ERK and JNK, through the activation of DUSP-2 which acts as ERK and JNK phosphatase [16]. This evidence concerns the gene MAPK8 and glioblastoma.