Moreover, it was observed that the CNE-2 cells (NPC), treated with variable doses of Berberine (25–100 μmol/L) for 24 h and γ-irradiation (4–8 Gy) were characterized by a decrease of the mRNA and by a down-regulation of the protein expression of Sp1, a transcription factor associated to the tumoral migration [135,136,137] and correlated to the tumoral invasion and radioresistance in NPC patients [138]. This evidence concerns the gene SP1 and nasopharyngeal carcinoma.