In this case, the radiosensitizing activity of RV relied on the inhibition of the phosphorylated form of AKT by downregulating E2F1. Moreover, the administration of resveratrol in xenograft tumor mice models of NPC, with 50 mg/kg/day and irradiated (4 Gy/day) for consecutive 3 days, significantly reduced tumor volume and weight of mice treated compared to the once treated with IR or RV alone [31]. Here, E2F1 is linked to neoplasm.