Indeed, similarly to PC-3 cells, HCT116 and HT29 human colorectal cancer cell lines treated with Curcumin at a concentration of 25 μM before a single dose of X-ray radiation (10 Gy) showed an enhanced radiosensitivity due to the suppression of both NFκB activity and NFκB-dependent anti-apoptotic (IAP2, Bcl-2, Bcl-XL), inflammatory (COX-2), proliferative (cyclin D1) and angiogenic (VEGF) target genes the expression of NFκB target genes [15]. The gene discussed is NFKB1; the disease is colorectal cancer.