CASP3 and non-small cell lung carcinoma: In addition, ZER enhanced the cleavage of Caspase 3 and PARP. Furthermore, the same combined treatment, used in in vivo nude mice models after grafting of NCI-H460 and NCI-H1299 non-small cell lung cancer (NSCLC) cells, inhibited the binding of HSP27 to apoptotic molecules such as Cytochrome c or PKCδ [60].