Data mining analysis has shown that even though the mRNA levels of all LPARs (LPAR1–6) and ATX are increased in the liver upon chronic liver diseases of different etiology (viral, alcohol, metabolic) and in the stage of liver cirrhosis, in the context of HCC only ATX, LPAR2 and LPAR6 are increased in the liver tumor compared to non-tumoral areas [152]. Here, ENPP2 is linked to cirrhosis of liver.