EGFR and osteosarcoma: Recent research corroborates the LPA-mediated induction of invasion and metastasis through LPAR1, Epidermal growth factor receptor (EGFR) transactivation and invadopodia formation in various cancer cell lines [110], through LPAR2 and Notch signaling in gastric cancer cells [111], or through LPAR2 in osteosarcoma cells [112].