Moreover, LPA aids cancer cells in adapting to the hypoxic environment through induction of Vascular endothelial growth factor (VEGF), its receptor (VEGFR2) and Hypoxia-Inducible-Factor-1-Subunit-Alpha (Hif-1α) ([101] and references therein) and tightens endothelial cell-cell contact promoting capillary network formation [115], thus satisfying the cancer hallmark of angiogenesis. The gene discussed is HIF1A; the disease is cancer.