LPA and hepatocellular carcinoma: Even though Hep-specific deletion of Enpp2 reduces effectively the liver ATX/LPA levels in the fibrotic phase of the CCl4/DEN model (>95% reduction for both), this reduction is milder in the HCC phase (40% reduction for LPA, 80% reduction for ATX) [152] suggesting that even a 40% reduction of LPA is sufficient to significantly reduce tumor growth.