Increased LPA levels have been found in hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), ovarian carcinoma, pancreatic cancer, thyroid cancer, multiple myeloma and follicular lymphoma [2,99] whereas increased ATX levels have been detected in glioblastoma multiforme, melanoma, breast cancer, HCC, NSCLC, renal cell carcinoma, thyroid cancer, ovarian cancer, pancreatic cancer and several lymphomas [2]. Here, ENPP2 is linked to familial pancreatic carcinoma.