Of note, an ATX inhibitor, GLPG1690, is in phase III clinical trials (ISABELA 1 and 2; NCT03711162; NCT03733444) and an LPAR1 inhibitor, BMS-986020, is in phase II clinical trials for the treatment of IPF [77,78]. This evidence concerns the gene ENPP2 and idiopathic pulmonary fibrosis.