All other cell lines investigated, the neuroblastoma cell lines SiMa, SK-N-SH and SH-SY5Y, the SCLC cell lines OH-1, NCI-H69 and NCI-H82, the lung adenocarcinoma cell line A549, the colon carcinoma cell lines SW480 and LoVo, the hepatocellular carcinoma cell lines HepG2 and SK-HEP-1, the renal cell carcinoma cell line A498, the urinary bladder carcinoma cell lines T24 and RT-112, the prostate cancer cell line DU145, the cervical cancer cell lines SW756, SiHa, CaSki and HeLa, and the ovarian carcinoma cell line SK-OV-3, were devoid of GPR68 expression. This evidence concerns the gene GPR68 and neuroblastoma.