The top 10 REACTOME pathways obtained from the list of TTYH3 and positively correlated genes were mainly related to the activation of the complement system (C3 and C5), loss of function of TGFBR1 in cancer, TGFBR1 kinase domain mutants in cancer, signaling by transforming growth factor-beta receptor complex in cancer, transmembrane transport of small molecules, degradation of heme protein, metabolism, diseases of signal transduction, biotin transport into cells and metabolism, and fibroblast growth factor receptor 4 ligand binding and activation (Figure 8a). Here, C5 is linked to cancer.