Furthermore, the top 10 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for TTYH3 and its positively correlated genes were mainly related to amyotrophic lateral sclerosis, small cell lung cancer, Staphylococcus aureus infection, chronic myeloid leukemia, renin-angiotensin system, complement and coagulation cascades, vitamin digestion and absorption, toxoplasmosis, and nuclear factor-kappa-B signaling pathways (Figure 8b). Here, REN is linked to amyotrophic lateral sclerosis.