ADCY8 and breast cancer: While the role of AC8 in cell migration might be attributed to impairment of Orai1 inactivation and, thus, the support of Ca2+ influx, we cannot rule out the possibility that cAMP generation by AC8 also plays a role in breast cancer cell migration, as PKA activation in MDA-MB-231 and MCF7 cells by the cAMP analogue 8-bromo-cAMP per se enhances cell migration and, conversely, pharmacological PKA inhibition attenuates it.