BCL2 and Ewing sarcoma: Inhibition of PI3K and its downstream signaling was observed to enhance apoptosis in Ewing’s sarcoma, while treatment of PI3K inhibitors in neuroblastoma cells was found to target anti-apoptotic BCL-2 family proteins and further promote mitochondrial apoptosis through chemosensitization, thus emphasizing the association between PI3K and BCL-2 family-mediated apoptosis [96,97].