ABCG2 and familial pancreatic carcinoma: Taking together, our intracellular bioluminescent pharmacokinetic data and the expression of ABCG2 and ABCB1 both suggest that the improvement of anti-pancreatic cancer efficacy when combined gemcitabine with coix seed extract may at least partly due to that coix seed extract could reverse gemcitabine induce mediated drug efflux function mediated ABCG2 and ABCB1.