ABCB1 and familial pancreatic carcinoma: Our current data and previous study [17] both showed that the ABCG2 and ABCB1 inhibitor could also regulate the intracellular bioluminescent signal intensity with or without the present of gemcitabine, we are going to employ some classical ABC transporter inhibitors and CRISPR mediated knockout approaches to further investigate the molecular functions that ABC transporters might play in the synergistic effect of coix seed extract and gemcitabine combination against pancreatic cancer cells.