As shown in Figure 6A, gemcitabine treatment can upregulate ABCB1 and ABCG2 level in cell membrane protein fraction to 2.0-fold (p < 0.01) and 3.8-fold (p < 0.05) in pancreatic cancer cell BxPC3luc compared with DMSO, while the coix seed extract treatment decreased ABCB1 and ABCG2 level in cell membrane protein fraction to 15.0-fold (p < 0.05) and 6.8-fold (p < 0.01). This evidence concerns the gene ABCG2 and familial pancreatic carcinoma.