AKT1 and neoplasm: Moreover, ROS can specifically hyperactivate the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways, stimulating some intracellular signaling cascades, and resulting in tumor development and metastasis through the regulation of cellular phenotypes including cancer cells survival, proliferation, and angiogenesis [38].