Recent studies demonstrated that RAD52 has an important role in genomic stability maintenance and cancer suppression in mammalian cells, while several HR proteins including BRCA1, BRCA2, PALB2, and RAD51 paralogs (RAD51B, C, D, and XRCC 2 and 3) present an inactivated and depleted activity [28,29,30]. This evidence concerns the gene PALB2 and cancer.