NOTCH3 and neoplasm: Because we hypothesized that the extent of ENT1, NOTCH3, and miR-21 deregulation in PDAC might be dependent on their levels in corresponding normal pancreas, we divided patients based on the median of expression of each marker in healthy pancreas (high >50%; low <50%) and compared the expression of each marker in tumor and normal pancreas in these subgroups in paired fashion.