Down-regulation of Prdx6 with specific siRNA decreased proliferation and induced apoptosis in canine haemangiosarcoma cells [21], whereas overexpression of Prdx6 attenuated apoptosis in ovarian cancer cells [22] and promoted growth of lung tumors in mice through activation of JAK2/STAT3 signaling [23]. The gene discussed is PRDX6; the disease is ovarian cancer.