In view of the above-outlined background of contrasting reports on the roles and mechanisms of multifunctional Prdx6 in several pathologies and its sensitivity to the redox environment, we have undertaken a project based on down-regulating Prdx6 with specific siRNA in hepatoblastoma HepG2 cells to study the role of Prdx6 in cell proliferation, redox homeostasis and metabolic programming. This evidence concerns the gene PRDX6 and hepatoblastoma.