In the reduced model of multivariable analysis, which was developed with backward variable selection method, only lymph node involvement (adjusted OR (95% CI): 8.71 (1.88–40.35), p = 0.0057) and bone metastasis (adjusted OR (95% CI): 9.65 (1.72–54.05), p = 0.0099) remained the independent predicting factors for concordant EGFR mutation test results in liquid/tissue biopsy. The gene discussed is EGFR; the disease is bone metastasis.