Dual MAPK pathway inhibition (dabrafenib and trametinib) was proven to have strong anti-tumor activity and good safety profile in patients with BRAF-mutant melanoma brain metastases [116], BRAF-mutant NSCLC [117], and KRAS-mutant-positive NSCLC [118]. The gene discussed is BRAF; the disease is non-small cell lung carcinoma.