Next, 21α-methylmelianodiol (21α-MMD), a bioactive derivative from Poncirus trifoliata, has important anti-tumor effects in lung cancer via interference with PI3K/AKT/AMPK and MAPK signaling; it was also associated with MDR (multi-drug resistance) reversal by reduction of P-gp/MDR1 (P-glycoprotein/multidrug resistance protein 1) expressions and its related role, with a further impact on paclitaxel sensitivity [149]. This evidence concerns the gene AKT1 and neoplasm.