The basis of the rs26232 association with both RA radiological severity and RASF behaviour in vitro could arise from several other mechanisms; the eQTL for C5orf30 may only be manifest in the context of the complex inflammatory and hypoxic environment of the RA joint, or be restricted to a different cell type, or could be the result of altered expression of one of the nearby genes. Here, MACIR is linked to rheumatoid arthritis.