In this regard, mutant IDH-driven epigenetic changes make glioma cells more susceptible to additional oncogenic events during multiple clonal evolution [38], as exemplified by 1p19q codel and inactivating alterations in tumor protein p53 (TP53), homolog of drosophila capicua (CIC) and alpha thalassemia/mental retardation syndrome X-linked (ATRX) [39,40]. This evidence concerns the gene IDH2 and glioma.