3-Piperidinylethoxy-anilinoquinazoline (PAQ) an analog to TKI vandetanib, with 40-fold stronger inhibitory properties for the VEGFR-2, was labeled with 11C and used as PET probe for monitoring anticancer treatment in the MMTV-PyMT/FVB (PyMT) transgenic mouse breast cancer model [40]. Here, KDR is linked to breast carcinoma.