EGFR and non-small cell lung carcinoma: Prominent examples of mutated signaling proteins in NSCLC include: the epidermal growth factor receptor (EGFR), the Kirsten rat sarcoma viral oncogene homolog GTPase (KRAS), BRAF, a member of the rapidly accelerated fibrosarcoma (RAF) family and the fusion oncogene echinoderm microtubule associated protein-like 4-anaplastic lymphoma receptor tyrosine kinase (EML4-ALK).