Based on in vitro activities of Oxy210 in NSCLC tumor cells, blocking their proliferation, epithelial-mesenchymal transition (EMT), invasive activity, inhibition of their TGF-β induced drug resistance and the pharmacological profile presented here, Oxy210 may be a suitable candidate for future studies directed toward therapeutic development in NSCLC. This evidence concerns the gene TGFB1 and neoplasm.