Moreover, MIR452 regulated two VEGFA–VEGFR2-mediated signaling pathways (VEGFR2–SRC–PTK2 and VEGFR2–KRAS–BRAF–MAPK), and as a result, MIR452 regulated cell growth, cell migration, and angiogenesis via the VEGFA–VEGFR2 pathway in CRC cells. This evidence concerns the gene PTK2 and colorectal carcinoma.