On the other hand, it has been observed that the administration of EGCG decreased serum levels of AST and ALT, decreased MDA levels in the liver, and remarkably restored the liver activities of SOD and GSH-Px in high-fat-induced obesity mice model [20], but it did not affect the trace element content in serum, tissues, and egg. This evidence concerns the gene SOD1 and obesity due to melanocortin 4 receptor deficiency.