CBS and hyperhomocysteinemia: Evidence from several preclinical models showed that the depletion of H2S levels is implicated in bone loss; data were reported in ovariectomized mice [14,91], in H2S-deficient CBS+/− mice [15], in a model of H2S-deficiency linked to diet-induced hyperhomocysteinemia [16,92], and in methionine-restricted fed rats [93].