For instance, its combination with metformin downregulated the expression of Trx1 and improved the efficacy of Sorafenib in the treatment of HCC, decreasing tumor invasiveness and cell motility [31], while its combination with tetrandrine was described to induce apoptosis through ROS/Akt signaling in human HCC [48]. Here, AKT1 is linked to hepatocellular carcinoma.