The finding of a significant decrease in succinate dehydrogenase (SDH) and isocitrate dehydrogenase (IDH) in the Tricarboxylic Acid Cycle (TCA) cycle in the most de-differentiated SNU475 cells (Supplementary File S1), together with a specific activation of a few upstream regulators, including SNAI1 (Figure 2B), agrees with the report that silencing or mutation of both enzymes promoted cell migration and invasion in different types of cancer cells mediated by TGF-ß/SNAI1 [38,39]. This evidence concerns the gene IDH3A and cancer.